Main Information

Target

FKBP1B

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human FKBP1B

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human FKBP1B AA range: 35-85

Specificity:

This antibody detects endogenous levels of human FKBP1B

Gene Name:

FKBP1B FKBP12.6 FKBP1L FKBP9 OTK4

Protein Name:

FKBP1B

Other Name:

Peptidyl-prolyl cis-trans isomerase FKBP1B ;
PPIase FKBP1B ;
12.6 kDa FK506-binding protein ;
12.6 kDa FKBP ;
FKBP-12.6 ;
FK506-binding protein 1B ;
FKBP-1B ;
Immunophilin FKBP12.6 ;
Rotamase ;
h-FKBP-12 ;

Database Link:

Organism	Gene ID	SwissProt
Human	2281;	P68106;

Background:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008],

Function:

Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by both FK506 and rapamycin.,Function:Associates with the ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. There are four molecules of FKBP12.6 per heart muscle RYR. Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the FKBP-type PPIase family. FKBP1 subfamily.,similarity:Contains 1 PPIase FKBP-type domain.,tissue specificity:Ubiquitous for both isoforms with highest levels in brain and thymus.,

Cellular Localization:

Cytoplasm . Sarcoplasmic reticulum .

Tissue Expression:

Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.