Main Information

Target

APOC2

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

WB, IHC, IF, ELISA

MW

11kD (Calculated)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human APOC2

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Calculated)

11kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human APOC2 AA range: 1-50

Specificity:

This antibody detects endogenous levels of human APOC2

Gene Name:

APOC2 APC2

Protein Name:

APOC2

Other Name:

Apolipoprotein C-II ;
Apo-CII ;
ApoC-II ;
Apolipoprotein C2 ;

Database Link:

Organism	Gene ID	SwissProt
Human	344;	P02655;

Background:

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011],

Function:

Disease:Defects in APOC2 are the cause of hyperlipoproteinemia type IB [MIM:207750]. It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.,Function:Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.,similarity:Belongs to the apolipoprotein C2 family.,tissue specificity:Secreted in plasma.,

Cellular Localization:

Secreted .

Tissue Expression:

Liver and intestine.

Research Areas:

>>Cholesterol metabolism