Main Information

Target

APOC1

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human APOC1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human APOC1 AA range: 1-50

Specificity:

This antibody detects endogenous levels of human APOC1

Gene Name:

APOC1 APOC1B

Protein Name:

APOC1

Other Name:

Apolipoprotein C-I ;
Apo-CIB ;
ApoC-IB ;
Apolipoprotein C1 ;
[Cleaved into: Truncated apolipoprotein C-I ;
Apo-CIB' ;
ApoC-IB' ;
]

Database Link:

Organism	Gene ID	SwissProt
Human	341;	P02654;

Background:

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016],

Function:

Function:Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein.,miscellaneous:Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).,online information:Apolipoprotein C1 entry,similarity:Belongs to the apolipoprotein C1 family.,tissue specificity:Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.,

Cellular Localization:

Secreted .

Tissue Expression:

Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.

Research Areas:

>>Cholesterol metabolism