Main Information

Target

RPAB4

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human RPAB4

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human RPAB4 AA range: 1-50

Specificity:

This antibody detects endogenous levels of human RPAB4

Gene Name:

POLR2K

Protein Name:

RPAB4

Other Name:

DNA-directed RNA polymerases I, II, and III subunit RPABC4 ;
RNA polymerases I, II, and III subunit ABC4 ;
ABC10-alpha ;
DNA-directed RNA polymerase II subunit K ;
RNA polymerase II 7.0 kDa subunit ;
RPB7.0 ;
RPB10alpha ;

Database Link:

Organism	Gene ID	SwissProt
Human	5440;	P53803;

Background:

This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008],

Function:

Function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.,similarity:Belongs to the archaeal rpoP/eukaryotic RPC10 RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.,

Cellular Localization:

Nucleus .

Tissue Expression:

Ovary,Placenta,

Research Areas:

>>RNA polymerase ;
>>Cytosolic DNA-sensing pathway ;
>>Huntington disease