Main Information

Target

SEC61B

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human SEC61B

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human SEC61B AA range: 30-110

Specificity:

This antibody detects endogenous levels of human SEC61B

Gene Name:

SEC61B

Protein Name:

SEC61B

Other Name:

Protein transport protein Sec61 subunit beta

Database Link:

Organism	Gene ID	SwissProt
Human	10952;	P60468;

Background:

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008],

Function:

Function:Necessary for protein translocation in the endoplasmic reticulum.,similarity:Belongs to the SEC61-beta family.,subunit:Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.,

Cellular Localization:

Endoplasmic reticulum membrane ; Single-pass membrane protein .

Tissue Expression:

Brain,Embryonic kidney,Epithelium,Stomach mucosa,

Research Areas:

>>Protein export ;
>>Protein processing in endoplasmic reticulum ;
>>Phagosome ;
>>Vibrio cholerae infection