Main Information

Target

TRY2

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

IHC, IF, WB

MW

27kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human TRY2

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

27kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human TRY2

Specificity:

This antibody detects endogenous levels of human TRY2

Gene Name:

PRSS2 TRY2 TRYP2

Protein Name:

TRY2

Other Name:

Trypsin-2 ;
Anionic trypsinogen ;
Serine protease 2 ;
Trypsin II ;

Database Link:

Organism	Gene ID	SwissProt
Human	5645;	P07478;

Background:

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015],

Function:

Catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,PTM:Sulfated on tyrosine.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,

Cellular Localization:

Secreted, extracellular space.

Tissue Expression:

Expressed in Paneth cells, at the base of small intestinal crypts.

Research Areas:

>>Neuroactive ligand-receptor interaction ;
>>Pancreatic secretion ;
>>Protein digestion and absorption ;
>>Influenza A