Main Information

Target

TIG1

Host Species

Rabbit

Reactivity

Human

Applications

IHC, IF, WB

MW

51kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human TIG1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

51kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human TIG1

Specificity:

This antibody detects endogenous levels of human TIG1

Gene Name:

RARRES1 TIG1

Protein Name:

TIG1

Other Name:

Retinoic acid receptor responder protein 1 ;
RAR-responsive protein TIG1 ;
Tazarotene-induced gene 1 protein ;

Database Link:

Organism	Gene ID	SwissProt
Human	5918;	P49788;

Background:

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],

Function:

induction:By tazarotene and by all the retinoic acid receptors tested.,similarity:Belongs to the protease inhibitor I47 (latexin) family.,

Cellular Localization:

Membrane ; Single-pass type III membrane protein .

Tissue Expression:

Skin,