Main Information

Target

CGT

Host Species

Rabbit

Reactivity

Human, Rat

Applications

IHC, IF, WB

MW

60kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human CGT

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

60kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human CGT

Specificity:

This antibody detects endogenous levels of human CGT

Gene Name:

UGT8 CGT UGT4

Protein Name:

CGT

Other Name:

2-hydroxyacylsphingosine 1-beta-galactosyltransferase ;
Ceramide UDP-galactosyltransferase ;
Cerebroside synthase ;
UDP-galactose-ceramide galactosyltransferase ;

Database Link:

Organism	Gene ID	SwissProt
Human	7368;	Q16880;

Background:

UDP glycosyltransferase 8(UGT8) Homo sapiens The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011],

Function:

Catalytic activity:UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.,Function:Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.,online information:2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor,pathway:Sphingolipid metabolism; galactosylceramide biosynthesis.,similarity:Belongs to the UDP-glycosyltransferase family.,

Cellular Localization:

Membrane ; Single-pass membrane protein . Endoplasmic reticulum .

Tissue Expression:

Brain,

Research Areas:

>>Ether lipid metabolism ;
>>Sphingolipid metabolism ;
>>Metabolic pathways