Main Information

Target

RAGE

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, IF, WB

MW

48kD (Observed)

Conjugate/Modification

Phospho

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous phospho levels of MOK (Phospho-Tyr161) at Human:Y161, Mouse:Y161, Rat:Y161

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

48kD

Modification

Phospho

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human MOK (Phospho-Tyr161)

Specificity:

This antibody detects endogenous phospho levels of MOK (Phospho-Tyr161) at Human:Y161, Mouse:Y161, Rat:Y161

Gene Name:

MOK RAGE RAGE1

Protein Name:

MOK (Phospho-Tyr161)

Other Name:

MAPK/MAK/MRK overlapping kinase ;
MOK protein kinase ;
Renal tumor antigen 1 ;
RAGE-1 ;

Database Link:

Organism	Gene ID	SwissProt
Human	5891;	Q9UQ07;

Background:

MOK protein kinase(MOK) Homo sapiens This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012],

Function:

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation appears to increase the enzymatic activity.,Function:Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.,

Cellular Localization:

Cytoplasm . Cell projection, cilium . Nucleus .

Tissue Expression:

Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.