Main Information

Target

Beta-defensin 1

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human Beta-defensin 1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human Beta-defensin 1 AA range: 1-50

Specificity:

This antibody detects endogenous levels of human Beta-defensin 1

Gene Name:

DEFB1 BD1 HBD1

Protein Name:

Beta-defensin 1

Other Name:

Beta-defensin 1 ;
BD-1 ;
hBD-1 ;
Defensin, beta 1 ;

Database Link:

Organism	Gene ID	SwissProt
Human	1672;	P60022;

Background:

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008],

Function:

Function:Has bactericidal activity.,mass spectrometry: PubMed:7628632,similarity:Belongs to the beta-defensin family.,tissue specificity:Plasma.,

Cellular Localization:

Secreted . Membrane . Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). .

Tissue Expression:

Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).

Research Areas:

>>ABC transporters ;
>>Staphylococcus aureus infection