Main Information

Target

Beta-defensin 4A

Host Species

Rabbit

Reactivity

Human

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human Beta-defensin 4A

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human Beta-defensin 4A AA range: 1-50

Specificity:

This antibody detects endogenous levels of human Beta-defensin 4A

Gene Name:

DEFB4A DEFB102 DEFB2 DEFB4; DEFB4B

Protein Name:

Beta-defensin 4A

Other Name:

Beta-defensin 4A ;
Beta-defensin 2 ;
BD-2 ;
hBD-2 ;
Defensin, beta 2 ;
Skin-antimicrobial peptide 1 ;
SAP1 ;

Database Link:

Organism	Gene ID	SwissProt
Human	100289462;	O15263;

Background:

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Jul 2008],

Function:

Function:Has antibacterial activity .,induction:By inflammation.,similarity:Belongs to the beta-defensin family. LAP/TAP subfamily.,tissue specificity:Expressed in the skin and respiratory tract.,

Cellular Localization:

Secreted.

Tissue Expression:

Expressed in the skin and respiratory tract.

Research Areas:

>>NOD-like receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Staphylococcus aureus infection