Main Information

Target

GNG2

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human GNG2

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human GNG2 AA range: 1-50

Specificity:

This antibody detects endogenous levels of human GNG2

Gene Name:

GNG2

Protein Name:

GNG2

Other Name:

Guanine nucleotide-binding protein G ;
I ;
/G ;
S ;
/G ;
O ;
subunit gamma-2 ;
G gamma-I ;

Database Link:

Organism	Gene ID	SwissProt
Human	54331;	P59768;

Background:

G protein subunit gamma 2(GNG2) Homo sapiens This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011],

Function:

Function:Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.,similarity:Belongs to the G protein gamma family.,subunit:G proteins are composed of 3 units, alpha, beta and gamma.,tissue specificity:Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.,

Cellular Localization:

Cell membrane ; Lipid-anchor ; Cytoplasmic side .

Tissue Expression:

Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.

Research Areas:

>>Ras signaling pathway ;
>>Chemokine signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apelin signaling pathway ;
>>Circadian entrainment ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>Serotonergic synapse ;
>>GABAergic synapse ;
>>Dopaminergic synapse ;
>>Relaxin signaling pathway ;
>>Morphine addiction ;
>>Alcoholism ;
>>Human cytomegalovirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer