Main Information

Target

HXA10

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

IHC, IF, WB

MW

42kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human HXA10

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

42kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human HXA10

Specificity:

This antibody detects endogenous levels of human HXA10

Gene Name:

HOXA10 HOX1H

Protein Name:

HXA10

Other Name:

Homeobox protein Hox-A10 ;
Homeobox protein Hox-1.8 ;
Homeobox protein Hox-1H ;
PL ;

Database Link:

Organism	Gene ID	SwissProt
Human	3206;	P31260;

Background:

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011],

Function:

Function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.,similarity:Belongs to the Abd-B homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,

Cellular Localization:

Nucleus.

Tissue Expression:

Caudate nucleus,Kidney,Muscle,Salivary gland,

Research Areas:

>>Transcriptional misregulation in cancer