Main Information

Target

GABA A Receptor α3

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

WB, IHC, IF

MW

55kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-2000; IHC 1:100-200; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

GABA A Receptor α3 protein(A225) detects endogenous levels of GABA A Receptor α3

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

55kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of GABA A Receptor α3 AA range: 51-101

Specificity:

GABA A Receptor α3 protein(A225) detects endogenous levels of GABA A Receptor α3

Gene Name:

GABRA3

Protein Name:

Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3)

Other Name:

Gamma-aminobutyric acid receptor subunit alpha-3 ;
GABA ;
A ;
receptor subunit alpha-3 ;

Database Link:

Organism	Gene ID	SwissProt
Human	2556;	P34903;
Mouse		P26049;
Rat		P20236;

Background:

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008],

Function:

Function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

Cellular Localization:

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue Expression:

Brain,

Research Areas:

>>Neuroactive ligand-receptor interaction ;
>>Retrograde endocannabinoid signaling ;
>>GABAergic synapse ;
>>Taste transduction ;
>>Morphine addiction ;
>>Nicotine addiction