Main Information

Target

KCNK4

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

IHC, IF

MW

43kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:100-200; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

KCNK4(TRAAK) protein(A238) detects endogenous levels of KCNK4(TRAAK)

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

43kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of KCNK4 (TRAAK) AA range: 38-88

Specificity:

KCNK4(TRAAK) protein(A238) detects endogenous levels of KCNK4(TRAAK)

Gene Name:

KCNK4

Protein Name:

Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK) (Two pore potassium channel KT4.1) (Two pore K(+) channel KT4.1)

Other Name:

KCNK4 ;
TRAAK ;
Potassium channel subfamily K member 4 ;
TWIK-related arachidonic acid-stimulated potassium channel protein ;
TRAAK ;
Two pore potassium channel KT4.1 ;
Two pore K ;
+ ;
channel KT4.1

Database Link:

Organism	Gene ID	SwissProt
Human	50801;	Q9NYG8;
Mouse		O88454;

Background:

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015],

Function:

Function:Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer .,

Cellular Localization:

Cell membrane ; Multi-pass membrane protein .

Tissue Expression:

Brain,Frontal cortex,