Main Information

Target

KCNK9

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

WB, IHC, IF

MW

42kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-2000; IHC 1:100-200; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

KCNK9(TASK-3) protein(A239) detects endogenous levels of KCNK9(TASK-3)

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

42kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of KCNK9 (TASK-3) AA range: 220-270

Specificity:

KCNK9(TASK-3) protein(A239) detects endogenous levels of KCNK9(TASK-3)

Gene Name:

KCNK9

Protein Name:

Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2) (Two pore K(+) channel KT3.2)

Other Name:

Potassium channel subfamily K member 9 ;
Acid-sensitive potassium channel protein TASK-3 ;
TWIK-related acid-sensitive K ;
+ ;
channel 3 ;
Two pore potassium channel KT3.2 ;
Two pore K ;
+ ;
channel KT3.2 ;

Database Link:

Organism	Gene ID	SwissProt
Human	51305;	Q9NPC2;
Mouse		Q3LS21;
Rat		Q9ES08;

Background:

This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Function:

Disease:Defects in KCNK9 may be the cause of a syndrome of mental retardation, hypotonia, and facial dysmorphism; also known as Birk Barel syndrome.,Disease:Overexpressed in a high proportion of breast cancers. May confer resistance to growth factor deprivation and hypoxia, thereby promoting tumor cell survival in poorly oxygenated areas of solid tumors.,Function:pH-dependent, voltage-insensitive, background potassium channel protein.,miscellaneous:Inhibited by phorbol 12-myristate 13-acetate (PMA). TASK-3 current is strongly decreased in the presence of an extracellular pH inferior to 7.0.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,tissue specificity:Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.,

Cellular Localization:

Cell membrane ; Multi-pass membrane protein .

Tissue Expression:

Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung.

Research Areas:

>>Aldosterone synthesis and secretion