Main Information

Target

Kv10.1

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

IHC, IF

MW

50kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:100-200; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

Kv10.1 protein(A259) detects endogenous levels of Kv10.1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

50kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of Kv10.1 AA range: 335-385

Specificity:

Kv10.1 protein(A259) detects endogenous levels of Kv10.1

Gene Name:

KCNG3

Protein Name:

Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3)

Other Name:

KCNG3 ;
Potassium voltage-gated channel subfamily G member 3 ;
Voltage-gated potassium channel subunit Kv10.1 ;
Voltage-gated potassium channel subunit Kv6.3

Database Link:

Organism	Gene ID	SwissProt
Human	170850;	Q8TAE7;
Mouse		P59053;
Rat		Q8R523;

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

Function:

Domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Function:Potassium channel subunit. Modulates channel activity.,similarity:Belongs to the potassium channel family. G subfamily.,subcellular location:Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.,subunit:Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers.,tissue specificity:Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord.,

Cellular Localization:

Cell membrane ; Multi-pass membrane protein . Cytoplasm . Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Remains intracellular in the absence of KCNB1 (PubMed:12060745). .

Tissue Expression:

Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745).