Main Information

Target

Kv10.2

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

WB, IHC, IF

MW

60kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-2000; IHC 1:100-200; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

Kv10.2 protein(A260) detects endogenous levels of Kv10.2

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

60kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of Kv10.2 AA range: 264-314

Specificity:

Kv10.2 protein(A260) detects endogenous levels of Kv10.2

Gene Name:

KCNH5

Protein Name:

Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (hEAG2) (Voltage-gated potassium channel subunit Kv10.2)

Other Name:

Potassium voltage-gated channel subfamily H member 5 ;
Ether-a-go-go potassium channel 2 ;
hEAG2 ;
Voltage-gated potassium channel subunit Kv10.2 ;

Database Link:

Organism	Gene ID	SwissProt
Human	238271;	Q8NCM2;
Mouse		Q920E3;
Rat		Q9EPI9;

Background:

This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Function:

Alternative products:Experimental confirmation may be lacking for some isoforms,Domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.,sequence Caution:Translated as Gly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG.,tissue specificity:Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.,

Cellular Localization:

Membrane; Multi-pass membrane protein.

Tissue Expression:

Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.