Main Information

Target

CTGF

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, IF, WB

MW

37kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human CTGF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

37kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human CTGF AA range: 130-210

Specificity:

This antibody detects endogenous levels of human CTGF

Gene Name:

CTGF CCN2 HCS24 IGFBP8

Protein Name:

CTGF

Other Name:

Connective tissue growth factor ;
CCN family member 2 ;
Hypertrophic chondrocyte-specific protein 24 ;
Insulin-like growth factor-binding protein 8 ;
IBP-8 ;
IGF-binding protein 8 ;
IGFBP-8 ;

Database Link:

Organism	Gene ID	SwissProt
Human	1490;	P29279;

Background:

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009],

Function:

Function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer.,

Cellular Localization:

Secreted, extracellular space, extracellular matrix . Secreted .

Tissue Expression:

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Research Areas:

>>Apelin signaling pathway ;
>>Hippo signaling pathway