RanbP3 Mouse Monoclonal Antibody (QYA10771)

产品名称：RanbP3鼠单克隆抗体

货号：QYA10771

 

主要参数

应用：WB

适应物种：Human, Mouse, Rat

分子量：70, 90KD

同种型：IgG1

储存温度：-20℃

建议工作浓度：WB:1000-2000

特异性：抗体可以检测内源性RanBP3蛋白

其他名称：DKFZp58611520, RANB3

 

背景

作为XPO1/CRM1介导的核输出的辅助因子，可能起输出复合物支架蛋白作用。与XPO1/CRM1结合后，稳定XPO1/CRM1与结合物的蛋白互作。在缺乏Ran结合型GTP的情况下，可阻止XPO1/CRM1与核孔复合体结合。与CHC1/RCC1结合并增加其鸟嘌呤核苷酸交换活性。以Ran依赖性方式将XPO1/CRM1募集至CHC1/RCC1。通过与R-SMAD蛋白(SMAD2和SMAD3)相互作用并介导其核输出，成为TGF-β信号通路的负调控因子。

 

 

注：本产品仅用于科研用途，不用于诊断和治疗。

Product name: RanbP3 Mouse Monoclonal Antibody

Cat: QYA10771

 

Main parameter

Applications: Western Blot (WB)

Reactivity: Human, Mouse, Rat

Protein MW: 70, 90 KD

Isotype: IgG1

Storage: -20℃

Recommended dilutions: WB:1000-2000

Specificity: Antibody can detects endogenous RanBP3 protein.

Alternative Names: DKFZp58611520, RANB3

 

Background

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. 

 

 

P.s. This product is only used for scientific research, not for diagnosis and treatment.