Main Information

Target

CD130/gp130

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

IHC, IF, WB

MW

130kD (Observed)

Conjugate/Modification

Phospho

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; WB 1:500-2000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous phospho levels of CD130/gp130 (Phospho-Ser782) at Human:S782, Mouse:S780

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

130kD

Modification

Phospho

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human CD130/gp130 (Phospho-Ser782)

Specificity:

This antibody detects endogenous phospho levels of CD130/gp130 (Phospho-Ser782) at Human:S782, Mouse:S780

Gene Name:

IL6ST

Protein Name:

CD130/gp130 (Phospho-Ser782)

Other Name:

Interleukin-6 receptor subunit beta ;
IL-6 receptor subunit beta ;
IL-6R subunit beta ;
IL-6R-beta ;
IL-6RB ;
CDw130 ;
Interleukin-6 signal transducer ;
Membrane glycoprotein 130 ;
gp130 ;
Oncostatin-M receptor subunit alpha ;
CD antigen CD130 ;

Database Link:

Organism	Gene ID	SwissProt
Human	3572;	P40189;

Background:

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014],

Function:

Disease:Isoform 2 is an autoantigen found in rheumatoid arthritis (RA) but it is not specific to patients with RA.,Domain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.,induction:Leukemia inhibitory factor (LIF) and Oncostatin-M (OSM) activate the type I OSM receptor while only OSM can activate the type II OSM receptor.,PTM:Heavily N-glycosylated.,PTM:Phosphorylation of Ser-782 down-regulates cell surface expression.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 5 fibronectin type-III domains.,subunit:Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST.,tissue specificity:Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.,

Cellular Localization:

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Tissue Expression:

Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). ; [Isoform 2]: Expressed in blood serum (at protein level) (PubMed:24629561).

Research Areas:

>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Signaling pathways regulating pluripotency of stem cells ;
>>JAK-STAT signaling pathway ;
>>Th17 cell differentiation ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Viral carcinogenesis