Main Information

Target

CCL17

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

WB, ELISA

MW

10kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-2000; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human CCL17

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

10kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human CCL17 AA range: 21-70

Specificity:

This antibody detects endogenous levels of human CCL17

Gene Name:

CCL17 SCYA17 TARC

Protein Name:

CCL17

Other Name:

C-C motif chemokine 17 ;
CC chemokine TARC ;
Small-inducible cytokine A17 ;
Thymus and activation-regulated chemokine ;

Database Link:

Organism	Gene ID	SwissProt
Human	6361;	Q92583;

Background:

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014],

Function:

Caution:Was originally (PubMed:9521068) thought to be a ligand for CCR8.,Function:Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.,induction:By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.,online information:CCL17 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.,

Cellular Localization:

Secreted.

Tissue Expression:

Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

Research Areas:

>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>Chemokine signaling pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway