Main Information

Target

Resistin

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human Resistin

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human Resistin AA range: 1-50

Specificity:

This antibody detects endogenous levels of human Resistin

Gene Name:

RETN FIZZ3 HXCP1 RSTN UNQ407/PRO1199

Protein Name:

Resistin

Other Name:

Resistin ;
Adipose tissue-specific secretory factor ;
ADSF ;
C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein ;
Cysteine-rich secreted protein A12-alpha-like 2 ;
Cysteine-rich secreted protein FIZZ3 ;

Database Link:

Organism	Gene ID	SwissProt
Human	56729;	Q9HD89;

Background:

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010],

Function:

Function:Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.,similarity:Belongs to the resistin/FIZZ family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed only in fatty tissues.,

Cellular Localization:

Secreted .

Tissue Expression:

Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues (PubMed:15064728). Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus (PubMed:15248836).