Main Information

Target

FXYD2

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human FXYD2

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human FXYD2 AA range: 10-90

Specificity:

This antibody detects endogenous levels of human FXYD2

Gene Name:

FXYD2 ATP1C ATP1G1

Protein Name:

FXYD2

Other Name:

Sodium/potassium-transporting ATPase subunit gamma ;
Na ;
+ ;
/K ;
+ ;
ATPase subunit gamma ;
FXYD domain-containing ion transport regulator 2 ;
Sodium pump gamma chain ;

Database Link:

Organism	Gene ID	SwissProt
Human	486;	P54710;

Background:

FXYD domain containing ion transport regulator 2(FXYD2) Homo sapiens This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011],

Function:

Disease:Defects in FXYD2 are the cause of hypomagnesemia type 2 (HOMG2) [MIM:154020]; also known as dominant renal hypomagnesemia or hypomagnesemia with hypocalciuria. HOMG2 is a disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria.,Function:May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.,sequence Caution:Wrong choice of frame.,similarity:Belongs to the FXYD family.,subunit:Composed of three subunits: alpha (catalytic), beta and gamma.,tissue specificity:Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.,

Cellular Localization:

Membrane ; Single-pass type III membrane protein .

Tissue Expression:

Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.

Research Areas:

>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Cardiac muscle contraction ;
>>Adrenergic signaling in cardiomyocytes ;
>>Insulin secretion ;
>>Thyroid hormone synthesis ;
>>Thyroid hormone signaling pathway ;
>>Aldosterone-regulated sodium reabsorption ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Proximal tubule bicarbonate reclamation ;
>>Salivary secretion ;
>>Pancreatic secretion ;
>>Carbohydrate digestion and absorption ;
>>Protein digestion and absorption ;
>>Bile secretion ;
>>Mineral absorption