Main Information

Target

COX7B

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

IHC, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-200; ELISA(peptide)1:5000-20000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human COX7B

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human COX7B AA range: 20-100

Specificity:

This antibody detects endogenous levels of human COX7B

Gene Name:

COX7B

Protein Name:

COX7B

Other Name:

Cytochrome c oxidase subunit 7B, mitochondrial ;
Cytochrome c oxidase polypeptide VIIb ;

Database Link:

Organism	Gene ID	SwissProt
Human	1349;	P24311;

Background:

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011],

Function:

Function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase VIIb family.,

Cellular Localization:

Mitochondrion inner membrane ; Single-pass membrane protein .

Tissue Expression:

Heart,Ovary,

Research Areas:

>>Oxidative phosphorylation ;
>>Metabolic pathways ;
>>Cardiac muscle contraction ;
>>Thermogenesis ;
>>Non-alcoholic fatty liver disease ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Diabetic cardiomyopathy