Main Information

Target

BEST2

Host Species

Rabbit

Reactivity

Mouse, Rat

Applications

WB, IHC, IF

MW

50kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-1000; IHC 1:200-500; IF 1:50-200

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous BEST2 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

50kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of BEST2

Specificity:

The antibody detects endogenous BEST2 protein.

Gene Name:

BEST2

Protein Name:

Bestrophin-2

Other Name:

Bestrophin-2 ;
Vitelliform macular dystrophy 2-like protein 1

Database Link:

Organism	Gene ID	SwissProt
Human	54831;	Q8NFU1;
Mouse		Q8BGM5;

Background:

This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008],

Function:

Function:Forms calcium-sensitive chloride channels. May conduct other physiologically significant anions such as bicarbonate.,similarity:Belongs to the bestrophin family.,tissue specificity:Mainly confined to the retinal pigment epithelium and colon.,

Cellular Localization:

Cell membrane; Multi-pass membrane protein.

Tissue Expression:

Mainly confined to the retinal pigment epithelium and colon.

Research Areas:

>>Salivary secretion