Main Information

Target

GAP-43

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB

MW

38,43kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-3000

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous GAP43 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

38,43kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Recombinant Protein of Neuromodulin

Specificity:

The antibody detects endogenous GAP43 protein.

Gene Name:

GAP43

Protein Name:

Neuromodulin

Other Name:

GAP43 ;
Neuromodulin ;
Axonal membrane protein GAP-43 ;
Growth-associated protein 43 ;
Neural phosphoprotein B-50 ;
pp46

Database Link:

Organism	Gene ID	SwissProt
Human	2596;	P17677;
Mouse	14432;	P06837;
Rat	29423;	P07936;

Background:

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function:

Function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,

Cellular Localization:

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .

Tissue Expression:

Alzheimer cortex,Brain,Subthalamic nucleus,