Main Information

Target

KCNN4

Host Species

Rabbit

Reactivity

Human, Rat, Mouse

Applications

WB, IHC, IF

MW

50kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-2000; IHC 1:50-100; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

KCNN4(SK4) protein(A247) detects endogenous levels of KCNN4(SK4)

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

50kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of KCNN4 (SK4) AA range: 177-227

Specificity:

KCNN4(SK4) protein(A247) detects endogenous levels of KCNN4(SK4)

Gene Name:

KCNN4

Protein Name:

Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)

Other Name:

KCNN4 ;
IK1 ;
IKCA1 ;
KCA4 ;
SK4 ;
Intermediate conductance calcium-activated potassium channel protein 4 ;
SK4 ;
SKCa 4 ;
SKCa4 ;
IKCa1 ;
IK1 ;
KCa3.1 ;
KCa4 ;
Putative Gardos channel

Database Link:

Organism	Gene ID	SwissProt
Human	3783;	O15554;
Mouse		O89109;
Rat		Q9QYW1;

Background:

potassium calcium-activated channel subfamily N member 4(KCNN4) Homo sapiens The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008],

Function:

Function:Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.,induction:Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells.,similarity:Belongs to the potassium channel KCNN family.,subunit:Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.,tissue specificity:Widely expressed in non-excitable tissues.,

Cellular Localization:

Cell membrane ; Multi-pass membrane protein .

Tissue Expression:

Widely expressed in non-excitable tissues.

Research Areas:

>>Insulin secretion ;
>>GnRH secretion ;
>>Salivary secretion ;
>>Protein digestion and absorption