Main Information

Target

Mas1

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, IHC, IF

MW

36-50kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:2000-5000; IHC 1:200-500; IF 1:50-200

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous Mas1 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

36-50kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of Mas1

Specificity:

The antibody detects endogenous Mas1 protein.

Gene Name:

MAS1

Protein Name:

Proto-oncogene Mas

Other Name:

MAS1 ;
MAS ;
Proto-oncogene Mas

Database Link:

Organism	Gene ID	SwissProt
Human	4142;	P04201;
Mouse		P30554;
Rat		P12526;

Background:

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012],

Function:

Caution:Was originally (PubMed:3419518) thought to be a receptor for angiotensin II.,Disease:The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Cellular Localization:

Cell membrane ; Multi-pass membrane protein .

Research Areas:

>>Neuroactive ligand-receptor interaction ;
>>Renin-angiotensin system ;
>>Coronavirus disease - COVID-19