Main Information

Target

TLR8

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, IF

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:200-500; IF 1:50-200

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous TLR8 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Recombinant Protein of TLR8

Specificity:

The antibody detects endogenous TLR8 protein.

Gene Name:

TLR8

Protein Name:

Toll-like receptor 8

Other Name:

Toll-like receptor 8 ;
CD288

Database Link:

Organism	Gene ID	SwissProt
Human	51311;	Q9NR97;
Mouse		P58682;

Background:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008],

Function:

Function:Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 24 LRR (leucine-rich) repeats.,subunit:Binds MYD88 via their respective TIR domains.,tissue specificity:Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.,

Cellular Localization:

Endosome membrane ; Single-pass type I membrane protein . Endosomal localization confers distinctive proteolytic processing. .

Tissue Expression:

Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.

Research Areas:

>>Neutrophil extracellular trap formation ;
>>Toll-like receptor signaling pathway ;
>>Coronavirus disease - COVID-19