Target：CP51A

Fields：Steroid biosynthesis;Metabolic pathways

Gene Name：CYP51A1 CYP51

Protein Name：Lanosterol 14-alpha demethylase (LDM) (EC 1.14.13.70) (CYPLI) (Cytochrome P450 51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)

Human Gene Id：1595

Human Swiss Prot No：Q16850

Mouse Swiss Prot No：Q8K0C4

Rat Swiss Prot No：Q64654

Immunogen：Synthesized peptide derived from human protein . at AA range: 210-290

Specificity：CP51A Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：55kD

Background：cytochrome P450 family 51 subfamily A member 1(CYP51A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

Function：catalytic activity:Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O.,cofactor:Heme group.,function:Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.,pathway:Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostrate, liver, kidney and lung.,

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .

Expression：Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.