Target：IL-5

Fields：Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway;Hematopoietic cell lineage;IL-17 signaling pathway;Th1 and Th2 cell differentiation;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;Intestinal immune network for IgA production;Pathways in cancer;Asthma;Autoimmune thyroid disease;Inflammatory bowel disease;Allograft rejection

Gene Name：IL5

Protein Name：Interleukin-5

Human Gene Id：3567

Human Swiss Prot No：P05113

Mouse Gene Id：16191

Mouse Swiss Prot No：P04401

Rat Swiss Prot No：Q08125

Immunogen：The antiserum was produced against synthesized peptide derived from human IL-5. AA range:43-92

Specificity：IL-5 Polyclonal Antibody detects endogenous levels of IL-5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL5;Interleukin-5;IL-5;B-cell differentiation factor I;Eosinophil differentiation factor;T-cell replacing factor;TRF

Observed Band(KD)：30kD

Background： This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013],

Function：function:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.,online information:Interleukin-5 entry,similarity:Belongs to the IL-5 family.,subunit:Homodimer; disulfide-linked.,

Subcellular Location：Secreted.